Paragon CleanPlex® NGS Panels – Simple

Pharmacogenomics Profiling to Identify Biomarkers of Drug Response

Pharmacogenomics (PGx) can enhance the accuracy of targeting patient therapy by enabling the use of an individual’s genome to assist predict drug response and guide optimal drug and dose selection. Ultimately, the goal is to provide safer, more impactful, and cost-effective treatment in patient therapy. Traditionally, pharmacogenomics is implemented reactively when there is a need to prescribe a high-risk drug. This is often expensive and suffers from a slow turnaround time. The field now recognizes the results and recommendations from pharmacogenomic profiling should be available preemptively in electronic health records and drug prescription systems.

Both pharmacogenomics research and clinical testing are converging from sequencing of the whole genome and testing of single targets, respectively, toward screening a panel of genes of pharmacological importance (pharmacogenes) and associating their variants to drug response. Amplicon-based targeted sequencing is an ideal approach for this screening because it is cost-effective and easy to implement in the laboratory. The workflow is fast and simple to carry out and allows researchers and assay developers to focus only on the pharmacogenes being investigated.

Obtain Accurate, Reproducible, and Highest-Quality Results to Predict Efficacy and Side Effects of Drugs

A third-party organization (an advanced molecular diagnostics company focused on precision medicine, non-invasive cancer testing, and digital health) developed CLIA-approved pharmacogenomics (PGx) NGS assay powered by Paragon Genomics’ CleanPlex technology. It was able to leverage CleanPlex technology’s ultra-high amplicon multiplexing capacity and extremely low PCR background to build a large 180-gene high-level evidence PGx panel that is both highly efficient and affordable. The NGS assay features a single-tube workflow that is easy to perform and minimizes the risk of handling errors.

CleanPlex Technology Highlights:

• Scalable High-Throughput System. Target thousands of relevant markers in the same assay.
• Fast Turnaround Time. Get custom assays delivered in 4 weeks. Our PhD-level expert scientists are here to provide speedy and comprehensive support throughout the design, ordering, and technology adoption process, including excellent after-sales technical support.
• Cost-Effective Solution. Process thousands of samples at a time on the Illumina® platform.
• Minimizes consumable consumption. This single-plate workflow reduces consumable costs and loss of material from the material transfer.
• Streamlined, Automation-Friendly Workflow. Generate sequencing-ready libraries in just 3 hours using a simple, three-step protocol that can be easily automated.
• High-Quality, Reproducible Results. Prepare high-quality NGS libraries with high marker call rates and efficient use of sequencing reads.